In the management of acute stent thrombosis, when might GP IIb/IIIa inhibitors be considered?

• A. As part of aggressive antiplatelet therapy if indicated
• B. They are never used
• C. They replace all antiplatelets
• D. They are used only after surgery

Answer: (D)

In acute stent thrombosis, you want rapid and strong platelet inhibition to restore flow and prevent further occlusion. GP IIb/IIIa inhibitors are potent intravenous antiplatelet agents that block the final common pathway of platelet aggregation. They’re used as part of aggressive antiplatelet therapy when indicated, typically during the immediate PCI or in high-thrombus situations, in addition to aspirin and a P2Y12 inhibitor. They’re not a replacement for all antiplatelets, and they’re not reserved only for after surgery. Bleeding risk must be balanced, but when rapid platelet suppression is needed to salvage a thrombosed stent, these agents are a helpful adjunct.