Premedication with steroids and antihistamines before contrast administration is intended to prevent what during imaging?

• A. Hypersensitivity reactions to contrast
• B. Coronary vasospasm
• C. Hemodynamic instability due to sedation
• D. Contrast-induced nephropathy

Answer: (B)

Premedication with steroids and antihistamines is aimed at reducing hypersensitivity reactions to iodinated contrast. Steroids dampen the inflammatory response and immune activation, while antihistamines block histamine-mediated symptoms such as itching, hives, and bronchospasm. This combination lowers the risk and severity of allergic-like reactions during the imaging study. It does not prevent coronary vasospasm, sedation-related hemodynamic instability, or contrast-induced nephropathy, which are managed with different strategies such as using alternative agents, ensuring hemodynamic stability, hydration, and limiting contrast dose.